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"She-Hulk has nothing to do with Captain America, why should I care?" you could be asking. You would be amazed, though. She-Hulk brought Intelligencia, a villainous group, to the MCU, and Leader from The Incredible Hulk most likely originated with them!
Indeed. Returning as Leader—a super-powered scientist fixated on gamma radiation—in Captain America: Brave New World is Tim Blake Nelson. This hypothesis also holds he is the brains behind Intelligence, the evil group causing She-Hulk's life to be difficult.
Leader is a major component of Intelligencia, a collection of the Marvel Universe's sharpest foes, in the comics. It so makes logical that he would be running the show in the MCU. Since Leader was quite fascinated in Bruce Banner's blood, this idea also clarifies the blood-obsessed plot from She-Hulk.
This is where things get truly fascinating now. Harrison Ford's character, President Ross, will turn Red Hulk in Captain America: Brave New World; the notion holds Leader is in charge of that metamorphosis. The Hulk has always captivated the leader, who might have even wished to design his own nemesis like to him.
You placed a bet! It very certainly sounds that way. There have been hints that Hulk will be very important in the future, and Captain America 4 might be preparing the ground for something huge. Introduced in She-Hulk, Skaar, the son of the Hulk, is a significant player in the World War Hulk comic line.
Consider intellect as a collection of extremely intelligent adversaries, akin to a hate group particularly directed toward female superheroes. They are planning to alter the fact that so many strong ladies surround since they dislike it.